Estimates the probability of reactive hemophagocytic syndrome from weighted clinical, laboratory, and marrow findings.
INSTRUCTIONS
Use this calculator by selecting the patient’s category for each HScore variable.
The total score is the sum of the selected points, which is then mapped to an estimated probability of hemophagocytic syndrome.
Known underlying immunosuppression*
Temperature*
<101.1 °F (<38.4 °C)0
101.1-102.9 °F (38.4-39.4 °C)+33
>102.9 °F (>39.4 °C)+49
Organomegaly*
No0
Hepatomegaly or splenomegaly+23
Hepatomegaly and splenomegaly+38
Number of cytopenias*
1 lineage0
2 lineages+24
3 lineages+34
Ferritin*
<2,0000
2,000-6,000+35
>6,000+50
Triglycerides*
<132.7 (<1.5)0
132.7-354 (1.5-4)+44
>354 (>4)+64
Fibrinogen*
>250 (>2.5)0
≤250 (≤2.5)+30
Aspartate aminotransferase*
<300
≥30+19
Hemophagocytosis features on bone marrow aspirate*
