export function calculateBreastCancerBrainMetastasisNomogram(input) { const { age, histologicalGrade, receptorStatus, delayToFirstMetastasis, nonbrainMetastaticSites } = input || {}; if ( age == null || histologicalGrade == null || receptorStatus == null || delayToFirstMetastasis == null || nonbrainMetastaticSites == null ) { return null; } const ageNum = Number(age); const histologicalGradeNum = Number(histologicalGrade); const receptorStatusNum = Number(receptorStatus); const delayNum = Number(delayToFirstMetastasis); const nonbrainMetastaticSitesNum = Number(nonbrainMetastaticSites); if ( !Number.isFinite(ageNum) || !Number.isFinite(histologicalGradeNum) || !Number.isFinite(receptorStatusNum) || !Number.isFinite(delayNum) || !Number.isFinite(nonbrainMetastaticSitesNum) ) { return null; } let agePoints; if (ageNum <= 14) { agePoints = 100; } else if (ageNum <= 24) { agePoints = 88; } else if (ageNum <= 34) { agePoints = 77; } else if (ageNum <= 44) { agePoints = 65; } else if (ageNum <= 54) { agePoints = 55; } else if (ageNum <= 64) { agePoints = 45; } else if (ageNum <= 74) { agePoints = 34; } else if (ageNum <= 84) { agePoints = 22; } else if (ageNum <= 94) { agePoints = 10; } else { agePoints = 0; } let delayPoints; if (delayNum <= 9) { delayPoints = 73; } else if (delayNum <= 21) { delayPoints = 70; } else if (delayNum <= 29) { delayPoints = 65; } else if (delayNum <= 41) { delayPoints = 60; } else if (delayNum <= 53) { delayPoints = 45; } else if (delayNum <= 71) { delayPoints = 35; } else if (delayNum <= 91) { delayPoints = 15; } else { delayPoints = 0; } const totalPoints = agePoints + histologicalGradeNum + receptorStatusNum + delayPoints + nonbrainMetastaticSitesNum; let probabilityOfBrainMetastasis; if (totalPoints <= 79) { probabilityOfBrainMetastasis = "<4%"; } else if (totalPoints <= 89) { probabilityOfBrainMetastasis = "4%"; } else if (totalPoints <= 124) { probabilityOfBrainMetastasis = "5%"; } else if (totalPoints <= 162) { probabilityOfBrainMetastasis = "10%"; } else if (totalPoints <= 187) { probabilityOfBrainMetastasis = "15%"; } else if (totalPoints <= 212) { probabilityOfBrainMetastasis = "21%"; } else if (totalPoints <= 237) { probabilityOfBrainMetastasis = "27%"; } else if (totalPoints <= 262) { probabilityOfBrainMetastasis = "38%"; } else { probabilityOfBrainMetastasis = "47%"; } return { totalPoints: `${totalPoints} points`, probabilityOfBrainMetastasis }; }

Nomogram for Breast Cancer Brain Metastasis

Nomogram for Breast Cancer Brain Metastasis